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Codeine is a type of medicine called a benzodiazepine. Benzodiazepines are used for their sedative and anxiety-relieving effects.
Codeine works by acting on receptors in the brain called GABA receptors. This causes the release of a neurotransmitter called GABA in the brain.
In acute alcohol withdrawal, Codeine may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis.
Codeine is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology (such as inflammation of the muscles or joints, or secondary to trauma); spasticity caused by upper motor neuron disorders (such as cerebral palsy and paraplegia); athetosis; stiff-man syndrome; and tetanus.
The effectiveness of Codeine in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
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